Fig. 7

Pathology of longitudinally extensive transvers myelitis-like lesions. Sagittal section of the spinal cord lesion in a 1 mg E5415A rat is shown (a) Multiple perivascular lesions, which were diffusely extended, coalesced with each to form lesions similar to longitudinally extensive transverse myelitis (LETM) lesions. Most of the infiltrating cells were polymorphonuclear leukocytes, and were markedly more present in the gray matter than in the white matter (b). These findings suggested that the mechanism underlying LETM is based on fusion of individual vasculocentric astrocytopathy lesions. Scale bar = 300 μm (Fig. 7a) and 40 μm (Fig. 7b)