Fig. 5
Pathology of optic neuritis and brain lesions. The localization of AQP4 loss in the optic nerve, peri-ventricles, and hypothalamus in the 1 mg E5415A injection (red in schema) and hIgGNMO (yellow in schema) (a). Peri-3rd ventricle lesions were bilaterally and diffusely extended along the ventricular wall (b). Optic tract lesion and optic chiasma lesion in a 20 mg hIgGNMO rat is shown (c−d). AQP4, EAAT2, and GFAP loss were observed in Iba1-positive peri-vascular areas. Optic chiasma lesions were located in the perivascular areas of the anatomical border between the optic chiasma and hypothalamus (d). Scale bar = 300 μm