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Table 2 Comparison of AD pathology in different species [5, 19, 25, 27, 31, 33, 39, 44, 48]

From: The domestic cat as a natural animal model of Alzheimer’s disease

Species Life span Tau Neuron loss
Sequence vs. human Oligomers SP Sequence vs. human Isoformsa NFT
Human 80 yrs Yes Yes 3R + 4R (6) Yes Yes
Chimpanzee 60 yrs 100 % ND Yes 100 % 3R + 4R (6) No No
Dog 20 yrs 100 % Yes Yes 92 % 3R + 4R (4) No No
Cat 20 yrs 1 a.a. different Yes No 93 % 3R + 4R (6) Yes Yes
Mouse 2 yrs 3 a.a. different No No 89 % 4R (3) No No
  1. aparenthesis indicate the number of total tau isoforms; yrs, years; a.a., amino acid(s); ND, no data