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Table 2 Comparison of AD pathology in different species [5, 19, 25, 27, 31, 33, 39, 44, 48]

From: The domestic cat as a natural animal model of Alzheimer’s disease

Species

Life span

Tau

Neuron loss

Sequence vs. human

Oligomers

SP

Sequence vs. human

Isoformsa

NFT

Human

80 yrs

Yes

Yes

3R + 4R (6)

Yes

Yes

Chimpanzee

60 yrs

100 %

ND

Yes

100 %

3R + 4R (6)

No

No

Dog

20 yrs

100 %

Yes

Yes

92 %

3R + 4R (4)

No

No

Cat

20 yrs

1 a.a. different

Yes

No

93 %

3R + 4R (6)

Yes

Yes

Mouse

2 yrs

3 a.a. different

No

No

89 %

4R (3)

No

No

  1. aparenthesis indicate the number of total tau isoforms; yrs, years; a.a., amino acid(s); ND, no data