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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: The domestic cat as a natural animal model of Alzheimer’s disease

Fig. 6

Hippocampal neuronal loss in cats with NFTs. a Immunohistochemistry for NeuN in young cats (Aβ–/NFT–, n = 3, mean age 3.7 years old), aged cats with Aβ deposits but no NFTs in the hippocampus (Aβ+/NFT–, n = 3, mean age 18 years old), and aged cats with Aβ deposits and NFTs (Aβ+/NFT+, n = 3, mean age 17.6 years old). Bar = 100 μm. b The number of NeuN-positive pyramidal cells shown in (a). The number of hippocampal neurons is significantly decreased in aged cats with Aβ deposits and NFTs (Aβ+/NFT+) compared to young cats (Aβ–/NFT–) and aged cats with Aβ deposits but no NFTs in the hippocampus (Aβ+/NFT–). *P < 0.001. c Ghost tangles are observed on an HE-stained section (arrows). In some of the cells, inclusions (composed of hyperphosphorylated tau, confirmed on consecutive sections) were observed (inset, arrowheads). Bar = 25 μm

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