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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: The domestic cat as a natural animal model of Alzheimer’s disease

Fig. 5

NFTs in aged cats brains. a Gallyas-Braak staining-positive argyrophilic aggregates are observed mainly in the neuronal soma, neurites, and also in some oligodendroglial cells (green arrowhead) in the entorhinal cortex of aged cat brain. Bar = 20 μm. b Transmission electron microscopy of NFT in the hippocampus. Bundles of filaments are observed in the neuronal soma either in strait form or paired twisted form. For the paired twisted form, the lengths between the constrictions (arrowheads) were 80-100 nm. Bars = 500 nm and 100 nm (inset). N: nucleus. c Consecutive sections of hippocampus show AT8-, AT100-, and ubiquitin-immunopositivity for NFTs. Bar = 100 μm. d AT8-positive (red) hyperphosphorylated tau is observed in MAP2-positive (green) neurons (left) and Olig2-positive (green) oligodendrocytes (right, white arrows), but not in GFAP-positive (green) astrocytes (middle). Bar = 50 μm

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