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Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss

Fig. 6

Presynaptic protein levels in the brains of terminal AD-ANCL patients. a Representative western blots (top) and semi-quantitative analysis (graph, bottom) displaying the protein levels of CSPα in the membrane (M-CSPα) (normalized to Flotillin) and cytosolic/soluble (S-CSPα) (normalized to HSC70) fractions from the occipital lobe of three controls and three terminal AD-ANCL patients. The graphs show the expression level of the indicated proteins normalized to flotillin or HSC70 expression. b Representative western blots (top) and semi-quantitative analysis (graph, bottom) show the protein levels of SNAP-25, vesicle-associated membrane protein 2 (VAMP2/ Synaptobrevin), Syntaxin 1 (STX1), and Synaptophysin (SYP) in the occipital lobe from three controls and three terminal AD-ANCL patients in the membrane fraction. Values represent the mean ± S.E.M. of three independent experiments. **, p ≤ 0.01; ***, p ≤ 0.001 using Student’s t test

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Acta Neuropathologica Communications

ISSN: 2051-5960

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