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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis

Fig. 7

CreERT2-mediated recombination in dentate gyrus and olfactory granule neurons is abrogated by dissolving TAM in wheat germ oil (WGO) rather than sunflower oil (SFO). a tdtomato expression in dentate gyrus (left panels) and OB (right panels). b Administering TAM in WGO produces a dramatic reduction in tdtomato expression in both hippocampus and OB, as well as in vasculature and ependymal cells (not shown). c the effects of TAM are partially-recapitulated by DPPE, a selective ChEH ligand. d quantitative effects of TAM in sunflower oil (n = 5) compared to wheat germ oil (n = 4). All images are single 1 μm-thick optical confocal sections. OB: olfactory bulb

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