Skip to main content
Fig. 6 | Acta Neuropathologica Communications

Fig. 6

From: Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis

Fig. 6

TAM induction of ATF3 expression occurs via ChEH inhibition. a Schematic indicating TAM targets (ERα: estrogen receptor alpha; σ1/σ2: sigma 1/2 receptors; ChEH: cholesterol-5,6-epoxide hydrolase), ChEH ligands (DPPE) and drugs used: ICI: ICI 182 780, a pure antiestrogen (n = 3); PPT: 4,4′,4″-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol, an ERα agonist (n = 3); DTG: ditolylguanidine, a sigma 1/2 receptor agonist (n = 3), vE: vitamin E. CE: ChEH substrate cholesterol epoxides; CT: ChEH products cholestane triol. b effects of SFO, WGO and drugs on recombination in the DRG. SFO: sunflower oil (n = 5); WGO: wheat germ oil (n = 4); vE: vitamin E (n = 6). c Only wheat germ oil significantly reduced recombination (P < 0.0001, one-way ANOVA). Note the decreased mean but increased variability in animals in which SFO was supplemented with vitamin E. d A single dose of DPPE, a selective ChEH ligand, induced significant recombination in the DRG

Back to article page