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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis

Fig. 2

a Allen Brain Atlas in situ hybridization studies of ATF3 mRNA expression in dentate gyrus and olfactory bulb. Sections are 25 μm thick. b In the absence of TAM, a few neurons have undergone recombination in the granular layer of the OB; with TAM, recombination is widespread and is far more than expected from Allen Brain Atlas ATF3 in situ hybridization studies. Insets are shown enlarged on the right. c–e TAM induces recombination in DG granule neurons, ependymal cells of the cerebral ventricles, in endothelial cells and in vascular smooth muscle cells (arrows in e). All sections (except those from the Allen Institute) are 30 μm thick and are single-plane images taken on a standard epifluorescence microscope. TAM: TAM. DG: dentate gyrus. OB: olfactory bulb. Image credit a: Allen Institute for Brain Science

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