Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

Table 2 Summary of intrastriatal injections into Tg(SNCA)1Nbm/J mice

Number of mice injected	Injected material^a	Time post-injection when the animal was euthanized (months)	Spread of pathology
4	30 μl PBS	3	No
4	30 μl PBS	6	No
4	30 μl PBS	9	No
4	30 μl MSA1 BE	3	No
4	30 μl MSA1 BE	6	Yes
4	30 μl MSA1 BE	9	Yes
4	30 μl MSA2 BE	3	No
4	30 μl MSA2 BE	6	Yes
4	30 μl MSA2 BE	9	Yes
4	30 μl iLBD1 BE	3	No
4	30 μl iLBD1 BE	6	Yes
4	30 μl iLBD1 BE	9	Yes
4	30 μl iLBD2 BE	3	No
4	30 μl iLBD2 BE	6	Yes
4	30 μl iLBD2 BE	9	Yes

PBS phosphate-buffered saline, BE brain extract, MSA multiple system atrophy, iLBD incidental Lewy body disease

ISSN: 2051-5960