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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

Fig. 5

Accumulation of inclusion bodies in Tg(SNCA)1Nbm/J mice injected with brain extracts from MSA or probable iLBD cases. a Confocal images show immunofluorescence staining with the 81A antibody for phosphorylated (S129) alpha-synuclein (red) at 9 months post injection in brain sections of Tg(SNCA)1Nbm/J mice injected with brain extracts from MSA or probable iLBD cases or PBS. Neurons were stained with an antibody against tubulin beta-3 chain (green) and nuclei with DAPI (blue). Staining for phosphorylated alpha-synuclein was absent in mice injected with PBS. In contrast, mice injected with brain extracts from MSA or probable iLBD cases accumulated inclusion bodies with staining for phosphorylated alpha-synuclein in many areas of the brain, including the cortex, striatum, hippocampus, brain stem, and cerebellum. b Confocal images with orthogonal projections show that inclusion bodies with staining for phosphorylated alpha-synuclein (red) were located within neuronal cell bodies. Scale bars = 10 μm

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