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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

Fig. 1

Brains of MSA and probable iLBD cases contain pathogenic alpha-synuclein. Immunohistochemical staining with an antibody against phosphorylated alpha-synuclein (81A) revealed glial cytoplasmic inclusions in cortical brain tissue sections from the MSA1 patient a and in cerebellar brain tissue sections from the MSA2 patient b. Staining of cortical brain tissue sections with the same antibody also showed granular deposits of phosphorylated alpha-synuclein in the cytoplasma and in neurites of cortical neurons from the iLBD1 c and iLBD2 cases d, e. Scale bar = 50 μm

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