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Table 2 Characteristics of HuAβ and MoAβ mouse models

From: Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

Mouse designation

PrP.HuAβ/PS1

PrP.MoAβ/PS1

PrP.HuAβ (GFP)

tet.HuAβ (107)

tet.MoAβ (GFP)

tet.HuAβ (GFP)

Aβ sequence

Human

Mouse

Human

Human

Mouse

Human

APP expression level

++

++

++

+++

++

+++

Age pathology first observed (months)

~6

~13

~12

~3

~13

~6

Cortical Pathology

P

P/M/WM

P

P

P

P

C

C

C/D

C

D

C/D

Hippocampal Pathology

P

P/M/WM

P/M

P

P

P

C

C

C/D

C

D

C

(very late)

Cerebellar Pathology

P/M/WM

P/M/WM

P/M

-

-

-

C

C

C

  1. P Parenchymal, M Meningeal, WM White matter tract distribution, C Cored, D Diffuse morphology
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Acta Neuropathologica Communications

ISSN: 2051-5960

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