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Table 2 Characteristics of HuAβ and MoAβ mouse models

From: Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

Mouse designation PrP.HuAβ/PS1 PrP.MoAβ/PS1 PrP.HuAβ (GFP) tet.HuAβ (107) tet.MoAβ (GFP) tet.HuAβ (GFP)
Aβ sequence Human Mouse Human Human Mouse Human
APP expression level ++ ++ ++ +++ ++ +++
Age pathology first observed (months) ~6 ~13 ~12 ~3 ~13 ~6
Cortical Pathology P P/M/WM P P P P
C C C/D C D C/D
Hippocampal Pathology P P/M/WM P/M P P P
C C C/D C D C
(very late)
Cerebellar Pathology P/M/WM P/M/WM P/M - - -
C C C
  1. P Parenchymal, M Meningeal, WM White matter tract distribution, C Cored, D Diffuse morphology