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Table 1 Comparison of the frequency of cerebellar amyloid deposits among the different lines of transgenic mice analyzed

From: Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits

Human Mouse
Transgenes PrP.HuAβ/PS1 PrP.HuAβ PrP.MoAβ/PS1
Line 85 57 C3.3xS9 Q2.2xS9 MHSI-695 D-943
Age (mo)* 16 21 18 22 20 24
Hippocampus +++ +++ +++ +++ +++ ++
Cerebellum +++ +++ + - + ++
  1. +: 1–5 plaques, ++: 6–20 plaques, +++: >20 plaques
  2. *Age analyzed