Fig. 5

Histologic comparison of amyloid plaque morphology in PrP.MoAβ/PS1 and PrP.HuAβ/PS1 mice. Representative images of cortical amyloid plaques in tissue sections stained with antibodies to GFAP, Aβ (mAb 4G8 and rAb Aβ42) and ubiquitin, and by Campbell-Switzer silver stain or Thioflavin-S staining. The images shown are representative of an analysis of at least 3 animals at each age and each genotype with at least 6 individual tissue sections taken from similar levels for each animal. All the images shown were obtained at the same magnification (40x) and digitally cropped