Fig. 6

Glial responses in PSAPP mice reconstituted with WT and Rag2 ko BM. a Astrogliosis is unchanged in Rag2 ko BM-transferred mice in comparison to WT BM-transferred PSAPP mice 6 months after reconstitution (at 18 months; representative images of cortical stainings are shown on the left). b Quantitative analysis of GFAP immunostainings. c, d Iba1 immunohistological analysis reveals a significant increase in microgliosis in Rag2 ko BM-recipient PSAPP mice in comparison to WT BM-transferred PSAPP mice. Scale bar = 300 μm (Insert: Scale bar = 40 μm). *p < 0.05. n = 8–10 per group