Fig. 5

Reduced Aβ load in PSAPP mice reconstituted with Rag2 ko BM a, b). Quantitative analysis of free-floating sections stained with the monoclonal anti-Aβ antibody 6E10 shows a 35 % reduction in the Aβ-immunoreactivity, but no significant change in Aβ-immunoreactive plaque number, in Rag2 ko BM-transferred PSAPP mice as compared to WT BM-transferred PSAPP mice 6 months after reconstitution (at 18 months of age; representative images of cortical stainings are shown in (a)). Scale bar = 300 μm. *p < 0.05. n = 8–10 per group. (c) Quantitative MSD analysis of plasma and cortical brain extracts reveals a significant reduction in formic acid soluble Aβ40 and Aβ42 along with an increase in plasma Aβ levels in PSAPP mice transferred with Rag2 ko BM in comparison with WT BM-transferred PSAPP mice. *p < 0.05. n = 9–10 per group