Fig. 5

ApoE levels in 85-day-old apoE^m/4 and APPPS1-21/apoE^m/4 brains. The cortices were homogenized in PBS, followed by 1 % Triton X-100 and 5 M guanidine and apoE levels were measured by ELISA. a-b Absolute concentrations and fractional distribution of mouse apoE and apoE4 in apoE^m/4 mice (n = 10). c-d Absolute concentrations and fractional distribution of mouse apoE and apoE4 in APPPS1-21/apoE^m/4 mice (n = 10; *p < 0.05; **p < 0.01; ***p < 0.001, Two-way ANOVA for repeated measures followed by Bonferroni post-test). e-g Correlations of Aβ₄₂ with mouse apoE, apoE4 and Aβ₄₀ in the insoluble fraction of APPPS1-21/apoE^m/4 cortices (n = 10)