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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

Fig. 4

Co-localization of mouse apoE and apoE4 in plaques within the same brain parenchyma in APPPS1-21/apoEm/4 mice. Brain sections from 85-day-old APPPS1-21/apoEm/4 animals (n = 7) were co-stained with HJ6.3-Alexa 568 for mouse apoE, HJ15.7-Alexa 488 for human apoE4, and X-34 for fibrillar amyloid. a Representative images and the % of plaques containing both mouse apoE and apoE4 (scale bar, 20 μm). b Representative images and the % of plaques containing only mouse apoE (scale bar, 20 μm)

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