Fig. 4

Co-localization of mouse apoE and apoE4 in plaques within the same brain parenchyma in APPPS1-21/apoE^m/4 mice. Brain sections from 85-day-old APPPS1-21/apoE^m/4 animals (n = 7) were co-stained with HJ6.3-Alexa 568 for mouse apoE, HJ15.7-Alexa 488 for human apoE4, and X-34 for fibrillar amyloid. a Representative images and the % of plaques containing both mouse apoE and apoE4 (scale bar, 20 μm). b Representative images and the % of plaques containing only mouse apoE (scale bar, 20 μm)