Fig. 1

ApoE4 shifted parenchymal Aβ deposition from plaques to parenchymal CAA in the 5XFAD mice. 8 ~ 10 months old 5XFAD/apoE^m/m, 5XFAD/apoE^m/4 and 5XFAD/apoE^4/4 mice were stained with X-34. a Representative brain sections with CAA (empty arrows) and plaques (solid arrows). Scale bar, 1 mm. The right panel is the high power magnification of the area labeled in the squares in the corresponding left-side images. b The % area covered by parenchymal fibrillar plaques in the cortex. c The % area covered by parenchymal CAA quantified in the cortex (n = 3-9/group; *p < 0.05, One-way ANOVA followed by Tukey post-test)