Fig. 6From: Two alternative pathways for generating transmissible prion disease de novo Plaques, perineuronal, perivascular or diffuse PrP depositions. PrP immunoreactivity stained with 3F4 antibody in subependymal (a), subpial (b), cerebellum white matter (c), or deeper layer of cortex (d) in animals from the second passage of F0.5-induced atypical PrPres that developed clinical disease. Red arrows point at perivascular deposition in c or perineuronal deposition in d. Scale bars = 50 μmBack to article page