Fig. 5From: Two alternative pathways for generating transmissible prion disease de novo Histopathological analysis. Spongioform changes stained with hematoxylin and eosine (upper panels) or PrP deposisiton stained with 3F4 antibody (lower panels) in hippocampus, thalamus, cerebellum, frontal cortex or caudoputamen in animals from the second passage of F0.5-induced atypical PrPres that developed clinical disease. Scale bars = 200 μmBack to article page