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Table 1 Pathological and clinical characteristics of FTD, AD and DLB patients used in FLNC brain expression studies

From: Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains

DR number Gender Age at onset (years) Age at death (years) Family History Clinical diagnosis Mutation Pathological diagnosis
DR287.1 F 65 71 F FTD GRN - p.A89Vfsa41 FTLD-TDP type A
DR2.3a F 63 71 F FTD GRN - p.0(IVS1 + 5G > C) FTLD-TDP type A
DR8.1 F 62 68 F FTD GRN - p.0(IVS1 + 5G > C) FTLD-TDP type A
DR25.5a M 70 73 F FTD GRN - p.0(IVS1 + 5G > C) FTLD-TDP type A
DR27.1 F 58 63 F FTD GRN - p.0(IVS1 + 5G > C) FTLD-TDP
DR28.1 M 56 62 F FTD GRN - p.0(IVS1 + 5G > C) FTLD-TDP type A
DR25.1 F 69 75 F FTD GRN - p.0(IVS1 + 5G > C) FTLD-TDP type A
DR40.1 F 44 56 F FTD VCP - p.R159H FTLD-TDP type D
DR40.7 M 49 57 F FTD VCP - p.R159H FTLD-TDP
DR7.4 M 63 68 F FTD VCP - p.R159H FTLD-U
ADR1 M 52 62 F FTD FLNC - p.V831I Pick’s disease
DR439.1 M 54 69 F FTD C9Orf72 - G4C2 expansion FTLD-TDP type B
DR29.1a F 50 55 F FTD C9Orf72 - G4C2 expansion FTLD-UPS
DR14.1a M 56 60 F FTD C9Orf72 - G4C2 expansion FTLD-TDP type B
DR386.1 M 72 83 S MXD unknown FTLD-TDP and AD
DR189.1 M 47 50 F FTD unknown FTLD-TDP type B
DR87.1 F 79 88 S FTD unknown FTLD TDP
DR864.1 M 59 62 S FTD - ALS unknown FTLD-TDP type B
DR102.1a F 72 79 S FTD unknown FTLD-TDP
DR246.1a M 62 72 F DLB unknown LBD
DR865.1 M 75 86 U AD unknown AD (III-IV Braak)
DR39.1a F 61 75 F AD APP - c.-369C/G AD-CAA
DS1.1a - - - S Down Syndrome 47XX,+21 or 47XY,+21 AD-CAA
  1. AD Alzheimer’s disease, APP amyloid precursor protein, CAA cerebral amyloid angiopathy, DLB dementia with Lewy bodies, UPS ubiquitin proteasome, system, DLBD diffuse Lewy body disease, F familial; S sporadic, U unknown, MXD mixed dementia, VCP valosin-containing protein
  2. Samples labeled with a were previously analyzed in FLNC expression studies published by Schmid et al. 2012 [12]