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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains

Fig. 1

FLNC variants identified in patients of the Belgian FTD cohort. a Schematic representation of the short and long isoform of FLNC, which differ from each other in the presence or absence of one exon (marked in red). b 19 FLNC variants identified in patients of the Belgian FTD cohort (marked in red) mapped on the domain structures of the FLNC gene. Represented variants were absent from 920 control individuals. Immunoglobulin (Ig)-like domains are numbered from 1 to 24. CH1 and CH2: calponin homology domains. Assignment of FLNC variants to the corresponding domain structure was based on the UniProt database (http://www.uniprot.org/)

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