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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity

Fig. 4

LPS treatment abolishes cellular LTP in the Schaffer collaterals, an effect partly rescued by activation of M1 muscarinic acetylcholine receptors. A 4× magnification image (a, scale bar 400 μm) and schematic representation (b) of an acute brain slice showing the recording (top) and stimulating (bottom left and middle) glass electrodes, DG: dentate gyrus. c Overlay of typical EPSC recordings evoked by stimulating the control and potentiation pathways during the baseline acquisition (1) and 50 min after LTP induction with high frequency stimulation (HFS: 4 × 100 pulses at 100 Hz every 60 s, scale bars: 100 pA, 50 ms) (2). d, e, g, h, j, k, m, n Time series plots show the mean (± SEM) EPSC amplitudes normalized to baseline for all cellular LTP experiments. (f, i, l, o) Overlaid timeplots of the mean EPSC amplitude data shown in (d, e, g, h, j, k, m, n). Control: n = 15 cells; LPS: n = 10 cells; control + apamin: n = 6 cells; LPS + apamin: n = 8 cells; control + physo: n = 6 cells; LPS + physo: n = 8 cells; control + TBPB: n = 7 cells; LPS + TBPB: n = 7 cells

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