Skip to main content
Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Muscarinic M1 receptors modulate endotoxemia-induced loss of synaptic plasticity

Fig. 3

LPS treatment modulates action potential (AP) afterhyperpolarization (AHP) of the hippocampal neurons. a Example trace of AP firing upon depolarizing 300 pA current injection in a control rat (ctrl, and Fig. 2b). AHP analysis was performed on the second last AP (scale bars: 10 mV, 200 ms). b Representative APs from CA1 pyramidal cells of each treatment group, superimposed and aligned to the peak amplitude of the spike (lower panel, scale bars: 5 mV, 10 ms) and the spike firing threshold (white circle, upper panel, scale bars: 2 mV, 10 ms). c, e Scatter plots show peak amplitude from all cells. Bars are means. d The post-burst hyperpolarization amplitude was quantified relative to the pre-burst resting membrane potential and the post-burst hyperpolarizing peak voltage. (scale bars: upper panel 10 mV, 200 ms; lower panel 2 mV, 200 ms). n.s.: not significant, ** p < 0.01, *** p < 0.001, ANOVA followed by Sidak’s multiple comparisons test. Control: n = 14 cells; LPS: n = 8 cells; control + apamin: n = 6 cells; LPS + apamin: n = 8 cells; control + physo: n = 6 cells; LPS + physo: n = 5 cells; control + TBPB: n = 7 cells; LPS + TBPB: n = 6 cells

Back to article page