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Table 3 Semi-quantitative scoring of neuropathological markers

From: Erratum to: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

  LBC AD   LBC AD
Region Stain Score Region Stain Score
BA9 TDP43 - ++ BA41/42 TDP43 - +
pTAU - +++ pTAU - +++
BA4 + +++ BA4 + +++
a-Syn - - a-Syn - -
GFAP + +++ GFAP ++ +++
CD68 + +++ CD68 + +
UBIQ + +++ UBIQ + +++
BA44/45 TDP43 + + EC TDP43 + ++
pTAU - +++ pTAU + +++
BA4 - +++ BA4 ++ +++
a-Syn - - a-Syn - -
GFAP + ++ GFAP + +++
CD68 ++ ++ CD68 + ++
UBIQ + +++ UBIQ ++ +++
BA46 TDP43 + ++ BA17 TDP43 + ++
pTAU - +++ pTAU - +++
BA4 - +++ BA4 + +++
a-Syn - - a-Syn - -
GFAP + ++ GFAP + +++
CD68 + ++ CD68 + +
UBIQ + +++ UBIQ + +++
BA6/8 TDP43 + ++ BA24 TDP43 + ++
pTAU - +++ pTAU - +++
BA4 + +++ BA4 - +++
a-Syn - - a-Syn - -
GFAP + +++ GFAP + ++
CD68 + +++ CD68 + ++
UBIQ + +++ UBIQ + +++
  1. BA9 = Prefrontal cortex, BA44/45 = Broca’s area, BA46 = Dorsolateral Prefrontal cortex, BA6/8 = Premotor cortex, BA41/42 = Superior Temporal cortex, EC = Entorhinal cortex, BA17 = Primary Visual cortex, BA24 = Anterior Cingulate cortex. “-” = no pathology, “+” = mild pathology, “++” = moderate pathology, “+++” = strong pathology. Example images for each score are found in Supplementary Figure 2.