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Table 1 Enrichment analysis of genes inversely correlated with C9orf72 mRNA levels

From: Gene co-expression analysis unravels a link between C9orf72 and RNA metabolism in myeloid cells

GO Term Adjusted p-value Genes
ncRNA metabolic process (GO:0034660) 6.57E-06 TRUB2;POP1;PARS2;PA2G4;EPRS;PDCD11;GEMIN5;TARS2;UTP20;IARS;FARSA;EARS2;AARS
tRNA aminoacylation for protein translation (GO:0006418) 6.57E-06 PARS2;TARS2;IARS;EPRS;FARSA;EARS2;AARS
tRNA aminoacylation (GO:0043039) 6.57E-06 PARS2;TARS2;IARS;EPRS;FARSA;EARS2;AARS
amino acid activation (GO:0043038) 6.57E-06 PARS2;TARS2;IARS;EPRS;FARSA;EARS2;AARS
cellular amino acid metabolic process (GO:0006520) 1.04E-05 PYCRL;PARS2;CAD;PYCR2;CTPS1;EPRS;PFAS;GLS;TARS2;IARS;FARSA;GART;EARS2;AARS
tRNA metabolic process (GO:0006399) 1.90E-05 TRUB2; POP1;PARS2;TARS2;IARS;EPRS;FARSA;EARS2;AARS
glutamine family amino acid metabolic process (GO:0009064) 0.0002 PYCRL;CAD;PYCR2;CTPS1;PFAS;GLS
  1. A gene enrichment analysis was performed on the list of top 100 genes that are the most inversely correlated with C9orf72 mRNA levels. Left column: GO terms for which enrichment was found; middle column: p-values adjusted from Fisher exact test; right column: C9orf72 inversely correlated genes annotated with the corresponding GO term. AARS: alanyl-tRNA synthetase; CAD: carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; CPTS1: CTP synthase 1; EARS2: glutamyl-tRNA synthetase 2, mitochondrial; EPRS: glutamyl-prolyl-tRNA synthetase; FARSA: phenylalanyl-tRNA synthetase, alpha subunit; GART: phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase; GEMIN5: gem (nuclear organelle) associated protein 5; GLS: glutaminase; IARS: isoleucyl-tRNA synthetase; PA2G4: proliferation-associated 2G4, 38kDa; PARS2: prolyl-tRNA synthetase 2, mitochondrial (putative); PDCD11: programmed cell death 11; PFAS: phosphoribosylformylglycinamidine synthase; POP1: processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae); PYCR2: pyrroline-5-carboxylate reductase family, member 2; PYCRL: pyrroline-5-carboxylate reductase-like; TARS2; threonyl-tRNA synthetase 2, mitochondrial (putative); TRUB2: TruB pseudouridine (psi) synthase family member 2; UTP20: UTP20, small subunit (SSU) processome component, homolog (yeast)