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Table 4 The difference between the mean volume of neuronal soma in control, dup(15) autism [dup(15)A] and idiopathic autism (iAutism) subjects

From: Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications

Brain structure

Mean volume of neuronal soma ± SD

Difference between groups (% and p<)

 

Control

Dup(15)A

iAutism

Control/Dup(15)A

Control/iAutism

iAutism/dup(15)A

Amygdala

2,424 ± 1,157

1,861 ± 1,048

2,327 ± 1,176

−23 % (0.000)

 

−20 % (0.024)

Thalamus

3,239 ± 1,379

2,678 ± 1,231

3,328 ± 1,430

−17 % (0.003)

  

Magnocellular LGN

4,397 ± 2,040

4,821 ± 1,969

4,716 ± 1,960

   

Parvocellular LGN

2,338 ± 855

2,395 ± 887

2,514 ± 881

 

+7 % (0.019)

−5 % (0.016)

Claustrum

1,914 ± 764

1,584 ± 739

1,582 ± 695

 

−17 % (0.004)

 

Caudate nucleus

1,133 ± 393

1,052 ± 366

1,286 ± 380

   

Putamen

931 ± 325

875 ± 300

1,022 ± 306

   

Nucleus accumbens

1,122 ± 313

919 ± 292

1,089 ± 327

−18 % (0.003)

  

G. pallidus ext.

5,438 ± 2,241

4,150 ± 1,931

5,117 ± 2,160

−24 % (0.001)

 

−19 % (0.048)

G. pallidus int.

6,670 ± 3,011

5,591 ± 2,715

6,069 ± 2,842

   

Magnocellular basal complex Ch1

6,252 ± 2,787

4,972 ± 2,894

4,729 ± 2,500

 

−24 % (0.002)

+5 % (0.009)

Ch2

6,966 ± 2,813

6,117 ± 2,800

5,507 ± 2,777

 

−21 % (0.007)

 

Ch3

9,592 ± 3,619

7,820 ± 3,291

7,122 ± 3,318

−18 % (0.030)

−26 % (0.000)

 

Ch4

11,314 ± 4,242

10,956 ± 3,890

9,949 ± 3,871

   

Substantia N. Dors.

9,527 ± 4,350

9,864 ± 4,403

9,162 ± 4,286

   

Substantia N. Ven.

11,138 ± 4,474

11,099 ± 4,607

10,417 ± 4,900

   

Ammon’s horn CA1

3,215 ± 1,241

2,801 ± 1,127

3,211 ± 1,233

   

CA2

5,204 ± 1,822

4,536 ± 1,717

5,696 ± 1,965

−13 % (0.014)

  

CA3

4,251 ± 1,624

3,450 ± 1,347

4,291 ± 1,596

−19 % (0.000)

 

−20 % (0.010)

CA4

4,855 ± 1,817

3,857 ± 1,615

5,087 ± 1,825

−20 % (0.001)

 

−24 % (0.000)

Entorhinal Cortex: LII, Islands

5,116 ± 1,960

4,102 ± 1,723

4,548 ± 1,991

−20 % (0.047)

  

EC LIII

2,403 ± 985

1,957 ± 885

2,311 ± 914

−19 % (0.049)

  

Purkinje cells

11,164 ± 3,948

9,818 ± 3,747

10,849 ± 3,934

 

−3 % (0.024)

 

Dentate nucleus

7,636 ± 4,414

6,547 ± 3,939

7,793 ± 4,541

   

Inferior olive

5,269 ± 1,978

4,610 ± 1,639

5,264 ± 1,883

−13 % (0.023)

  
  1. dup(15) chromosome 15q11.2-13.1 duplication syndrome, LGN lateral geniculate nucleus