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Table 4 The difference between the mean volume of neuronal soma in control, dup(15) autism [dup(15)A] and idiopathic autism (iAutism) subjects

From: Significant neuronal soma volume deficit in the limbic system in subjects with 15q11.2-q13 duplications

Brain structure Mean volume of neuronal soma ± SD Difference between groups (% and p<)
  Control Dup(15)A iAutism Control/Dup(15)A Control/iAutism iAutism/dup(15)A
Amygdala 2,424 ± 1,157 1,861 ± 1,048 2,327 ± 1,176 −23 % (0.000)   −20 % (0.024)
Thalamus 3,239 ± 1,379 2,678 ± 1,231 3,328 ± 1,430 −17 % (0.003)   
Magnocellular LGN 4,397 ± 2,040 4,821 ± 1,969 4,716 ± 1,960    
Parvocellular LGN 2,338 ± 855 2,395 ± 887 2,514 ± 881   +7 % (0.019) −5 % (0.016)
Claustrum 1,914 ± 764 1,584 ± 739 1,582 ± 695   −17 % (0.004)  
Caudate nucleus 1,133 ± 393 1,052 ± 366 1,286 ± 380    
Putamen 931 ± 325 875 ± 300 1,022 ± 306    
Nucleus accumbens 1,122 ± 313 919 ± 292 1,089 ± 327 −18 % (0.003)   
G. pallidus ext. 5,438 ± 2,241 4,150 ± 1,931 5,117 ± 2,160 −24 % (0.001)   −19 % (0.048)
G. pallidus int. 6,670 ± 3,011 5,591 ± 2,715 6,069 ± 2,842    
Magnocellular basal complex Ch1 6,252 ± 2,787 4,972 ± 2,894 4,729 ± 2,500   −24 % (0.002) +5 % (0.009)
Ch2 6,966 ± 2,813 6,117 ± 2,800 5,507 ± 2,777   −21 % (0.007)  
Ch3 9,592 ± 3,619 7,820 ± 3,291 7,122 ± 3,318 −18 % (0.030) −26 % (0.000)  
Ch4 11,314 ± 4,242 10,956 ± 3,890 9,949 ± 3,871    
Substantia N. Dors. 9,527 ± 4,350 9,864 ± 4,403 9,162 ± 4,286    
Substantia N. Ven. 11,138 ± 4,474 11,099 ± 4,607 10,417 ± 4,900    
Ammon’s horn CA1 3,215 ± 1,241 2,801 ± 1,127 3,211 ± 1,233    
CA2 5,204 ± 1,822 4,536 ± 1,717 5,696 ± 1,965 −13 % (0.014)   
CA3 4,251 ± 1,624 3,450 ± 1,347 4,291 ± 1,596 −19 % (0.000)   −20 % (0.010)
CA4 4,855 ± 1,817 3,857 ± 1,615 5,087 ± 1,825 −20 % (0.001)   −24 % (0.000)
Entorhinal Cortex: LII, Islands 5,116 ± 1,960 4,102 ± 1,723 4,548 ± 1,991 −20 % (0.047)   
EC LIII 2,403 ± 985 1,957 ± 885 2,311 ± 914 −19 % (0.049)   
Purkinje cells 11,164 ± 3,948 9,818 ± 3,747 10,849 ± 3,934   −3 % (0.024)  
Dentate nucleus 7,636 ± 4,414 6,547 ± 3,939 7,793 ± 4,541    
Inferior olive 5,269 ± 1,978 4,610 ± 1,639 5,264 ± 1,883 −13 % (0.023)   
  1. dup(15) chromosome 15q11.2-13.1 duplication syndrome, LGN lateral geniculate nucleus