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Table 1 Characteristics of study cohort

From: Cortical tau load is associated with white matter hyperintensities

 

AD

Control

Statistic (df, p-value)

n

23

13

 

Age, mean (±SD)

84.26 years (5.67)

84.77 (8.49)

t(34) = 1.194, p = 0.241

Gender M:F

10:13

8:7

χ 2 (1) = 0.444, p = 0.505

PMD, mean (±SD)

49.95, h (22.89)

47.15 (24.43)

t(33) = 0.34, p = 0.735

Thal Aβ phase20

Phase 5, n = 23

Phase 0, n = 5

U(34) = 0.000, p = 0.001

Phase 1, n = 3

Phase 2, n = 3

Phase 3, n = 1

Phase 4, n = 1

Braak NFT stage21

NFT stage 6, n = 23

NFT stage 0, n = 2

U(34) = 0.000, p = 0.001

NFT stage 1, n = 1

NFT stage 2, n = 3

NFT stage 3, n = 6

NFT stage 4, n = 1

CERAD22

C, n = 23

Negative, n = 10

-

A, n = 2

B, n = 1

NIA-AA23

High, n = 23

No, n = 5

-

Low, n = 7

Intermediate, n = 1

MMSE17 (±SD)

4.33 (3.9)

28 (2.09)

t(22) = 14.07, p = 0.001

  1. Abbreviations: AD Alzheimer’s disease, df degrees of freedom, t Independent samples test, X 2 Chi -squared test, F female, M Male, U Mann–Whitney U test, PMD post mortem delay, Aβ amyloid-beta, NFT neurofibrillary tangle, CERAD Consortium to Establish a Registry for Alzheimer's Disease, NIA-AA National Institute on Ageing - Alzheimer’s Association criteria for AD neuropathologic change, MMSE mini mental state examination
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Acta Neuropathologica Communications

ISSN: 2051-5960

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