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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: C9ORF72 expression and cellular localization over mouse development

Fig. 3

Expression of C9ORF72 isoforms over development. a Relative expression of C9orf72 isoforms 1, 2 and 3 mRNA in combined cerebral cortex and hippocampus of C57Bl/6 mice. Isoform 1 was significantly (p < 0.05) higher at P1 compared to P7 and P56 and isoform 2 was significantly (p < 0.05) higher at P56 compared to P1 and P7. b Western blot of C9ORF72 expression in mouse tissue over development. Bands corresponding to reported isoforms of C9ORF72 were present at 55, 50 and 35 kDa (b). Additional bands at 110 and 50 kDa were also present. GAPDH was used as a loading control. Values represent mean ± standard error. *p < 0.05 P1 and P7 vs. P56

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