TY - JOUR AU - Atkinson, Rachel A. K. AU - Fernandez-Martos, Carmen M. AU - Atkin, Julie D. AU - Vickers, James C. AU - King, Anna E. PY - 2015 DA - 2015/09/25 TI - C9ORF72 expression and cellular localization over mouse development JO - Acta Neuropathologica Communications SP - 59 VL - 3 IS - 1 AB - A majority of familial frontotemporal lobar dementia and amyotrophic lateral sclerosis cases are associated with a large repeat expansion in a non-coding region of the C9ORF72 gene. Currently, little is known about the normal function and the expression pattern of the C9ORF72 protein. The aims of this study were to characterize the expression pattern and cellular localization of the three reported mouse isoforms of C9orf72, over a developmental time-course in primary cultured cortical neurons and brain tissue from C57BL/6 mice. SN - 2051-5960 UR - https://doi.org/10.1186/s40478-015-0238-7 DO - 10.1186/s40478-015-0238-7 ID - Atkinson2015 ER -