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Fig. 5 | Acta Neuropathologica Communications

Fig. 5

From: Distribution of α-synuclein in the spinal cord and dorsal root ganglia in an autopsy cohort of elderly persons

Fig. 5

Schematic summarizing the propagation of α-synuclein. Red circles represent pathologic α-synuclein accumulation. Proposed pathway of the spread of LBAS from the RF or LC to the spinal gray matter (A), in the primary sensory neurons (B), in the preganglionic sympathetic nerves (C), and in the preganglionic parasympathetic nerves (D). AON, anterior olfactory nucleus; LC, locus ceruleus; Post-Sy, postganglionic sympathetic nerve; Pre-Sy, preganglionic sympathetic nerve; RF, medullary reticular formation; Sa-IML, nucleus of intermediolateral column of the sacral cord; Th-IML, nucleus of intermediolateral column of the thoracic cord. Pathway of the spread of LBAS in the olfactory nervous system (¶) [16, 18], and in cardiac postganglionic sympathetic nerves (§) [2]

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