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Fig. 1 | Acta Neuropathologica Communications

Fig. 1

From: ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation

Fig. 1

a Reveals marked neuronal loss in the anterior horn of the spinal cord with occasional surviving angulated neurons (arrows) in case 5 (p.R521H). H&E. b Well circumscribed basophilic inclusion (arrow) in an anterior horn neuron in case 6 (p.P525L and p.Y374X TARDBP mutation). This contrasts with an anterior horn neuron containing some basophilic aggregate-like inclusions (inset-case 2 (p.K510E)) which resemble condensed Nissl substance H&E. c Immunostaining for p62 illustrates neuronal (N) and glial cytoplasmic inclusions (G) in the anterior horns of the spinal cord. Case 1 (p.R495X). Anti p62. d-f. Reveal the differing shapes and conformations of FUS-positive neuronal cytoplasmic inclusions in the anterior horns of the spinal cords in case 1 (d-p.R495X), case 2 (e-p.K510E), and case 4 (f-p.R521C). Anti-FUS. Scale Bar (a)-140 μm, (b) (c) (e) and (b) inset-35 μm, (d) (f)-25 μm

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Acta Neuropathologica Communications

ISSN: 2051-5960

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