Fig. 3

T- and B-cell adoptive transfer. a IOP recordings in nee/Rag1 ⁻ splenocyte recipients (n=, CD3⁺ and CD19⁺ cell recipient animals. Data indicate that the transfer does not influence IOP and remains similar to IOP values of naïve mice. The mean IOP over all groups remains at 12.6 ± 2.8 mmHg (p > 0.5). Data are given as mean ± SD. b RGC density in nee/Rag1 ⁻ splenocyte recipients and CD19⁺ or CD3⁺ lymphocyte recipient mice 4 months after transfer. Transfer of nee CD3⁺ T-lymphocytes induces a significant loss of RGC in animals (N = 5) when compared to recipients of B6 CD3⁺ cells (N = 8), to B6 CD19⁺ lymphocyte recipients (N = 8), or to a naïve control group (N = 7, **p < 0.001). Adoptive transfer of the nee CD19⁺ fractions results in a modest, but not statistically significant, reduction of RGC in recipients (N = 5, p = 0.12) when compared to the corresponding B6 CD19⁺ lymphocyte recipients. Transfer of splenocytes from immunodeficient nee/Rag1 ⁻ donors did not result in loss of RGC in recipients (N = 6) when compared to naïve mice and animals having received lymphocytes from B6 donors (p < 0.84). Accordingly, RGC density is also significantly lower in nee when compared to nee/Rag1 ⁻ animals (^## p < 0.001). Triangles represent individual RGC data and the horizontal line designates the group average