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Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice

Fig. 4

Injection of ChABC into APPswe/PS1dE9 dorsal hippocampus results in reduced amyloid burden in the stratum lacunosum moleculare (slm). a a. Immunostaining for Aβ (rabbit anti-Aβ 95-2-5) showing whole brain section of ChABC injected APPswe/PS1dE9 mouse hippocampus at low magnification (25x); a b,a b’. Aβ immunostaining of slm on ChABC injected ipsilateral (a b) and contralateral (a b’) sides (100x). a c,a c’. inverted images of (a b and a b’). a d,a d’. PSD-95 staining in the same sections as in (a c,a c’) with slm outlined in blue. a e,a e’. sections from (a c,a c’) thresholded and converted to binary to calculate the area occupied by Aβ. b. Quantitative measurement of area occupied by Aβ in the slm as area occupied by Aβ (left graph; APPswe/PS1dE9 n = 7) and area occupied as per cent of contralateral side (right graph, no ChABC treatment n = 3; ChABC treatment n = 7). Comparison between treatments was made using unpaired Student’s t-test. *p < 0.05 was considered a significant difference between groups

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