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Fig. 3 | Acta Neuropathologica Communications

Fig. 3

From: Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice

Fig. 3

Intracerebral ChABC injection results in a marked and long-lasting decline in CS-bearing PGs. Low magnification micrographs (25x) of Wisteria floribunda agglutinin (WFA) staining 1, 2, and 3 weeks after ChABC injection (5 mU/1 μL). Arrowhead represents injection site for ChABC. Note the widespread loss of WFA immunoreactivity in the injected (left side) cortex and hippocampus (area with white outline). Injection target was to the ventral side of the corpus callosum on the dorsal side of dorsal hippocampus

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