Acta Neuropathologica Communications

Table 3 Semi-quantitative scoring of neuropathological markers

From: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

		LBC	AD			LBC	AD
Region	Stain	Score		Region	Stain	Score
BA9	TDP43	-	++	BA41/42	TDP43	-	++
	pTAU	-	+++		pTAU	-	+++
	BA4	+	+++		BA4	+	+++
	a-Syn	-	-		a-Syn	-	-
	GFAP	+	+++		GFAP	++	+++
	CD68	+	+++		CD68	+	+
	UBIQ	+	+++		UBIQ	+	+++
BA44/45	TDP43	+	+	EC	TDP43	+	++
	pTAU	-	+++		pTAU	+	+++
	BA4	-	+++		BA4	++	+++
	a-Syn	-	-		a-Syn	-	-
	GFAP	+	++		GFAP	+	+++
	CD68	++	++		CD68	+	++
	UBIQ	+	+++		UBIQ	++	+++
BA46	TDP43	+	++	BA17	TDP43	+	++
	pTAU	-	+++		pTAU	-	+++
	BA4	-	+++		BA4	+	+++
	a-Syn	-	-		a-Syn	-	-
	GFAP	+	++		GFAP	+	+++
	CD68	+	++		CD68	+	+
	UBIQ	+	+++		UBIQ	+	+++
BA6/8	TDP43	+	++	BA24	TDP43	+	++
	pTAU	-	+++		pTAU	-	+++
	BA4	+	+++		BA4	-	+++
	a-Syn	-	-		a-Syn	-	-
	GFAP	+	+++		GFAP	+	++
	CD68	+	+++		CD68	+	++
	UBIQ	+	+++		UBIQ	+	+++

BA9 = Prefrontal cortex, BA44/45 = Broca’s area, BA46 = Dorsolateral Prefrontal cortex, BA6/8 = Premotor cortex, BA41/42 = Superior Temporal cortex, EC = Entorhinal cortex, BA17 = Primary Visual cortex, BA24 = Anterior Cingulate cortex. “-” = no pathology, “+” = mild pathology, “++” = moderate pathology, “+++” = strong pathology. Example images for each score are found in Additional file 1: Figure S2

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