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Fig. 2 | Acta Neuropathologica Communications

Fig. 2

From: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

Fig. 2

In vivo MRI of the LBC1936 cohort reveals a broad spectrum of pathology. a FLAIR-weighted, coronal MR images from 12 individual LBC1936 participants, highlighting the range of gross brain pathology observed, such as ventricular enlargement and cortical atrophy. Pathology worsens from the top left to bottom right. b T2-weighted, horizontal MR images depicting the range of white matter hyperintensities observed in the LBC1936. Most are periventricular, but some appear to be subcortical. Again, pathology worsens from the top left to bottom right. c Coronal T1-weighted image from the LBC1936 participant who donated their brain for post-mortem study, revealing some cortical atrophy (red arrows). d Horizontal axial FLAIR-weighted MR image, revealing white matter hyperintensities (blue arrows). e Horizontal T2-weighted and GRE-weighted (f) MR images reveal generally good brain structure

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Acta Neuropathologica Communications

ISSN: 2051-5960

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