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Fig. 11 | Acta Neuropathologica Communications

Fig. 11

From: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

Fig. 11

Analysing the synaptic localization of β-amyloid and ApoE. a Histogram showing the percentage of synapses that exhibits co-localization between PSD95 and AW7 in the LBC1936 (black bars) and AD (grey bars) samples. The percentage of co-localization between PSD95 and ApoE in the LBC1936 and AD samples is shown in (b) c The percentage of co-localization between PSD95, ApoE and AW7 in the LBC1936 and AD samples. d Histogram showing the percentage of synapses that exhibits co-localization between synaptophysin and AW7 in the LBC1936 and AD samples. The percentage of co-localization between synaptophysin and ApoE in the LBC1936 and AD samples is shown in (e). f The percentage of co-localization between synaptophysin, ApoE and AW7 in the LBC1936 and AD samples. g Histogram representing the median post-synapse (PSD) volume of all synapses from all cortical regions, positive for PSD alone, or combinations of PSD ± pathology as noted on x-axis. h Histogram representing the median pre-synapse (synaptophysin) volume of all synapses from all cortical regions, positive for synaptophysin alone, or combinations of synaptophysin ± pathology as noted on x-axis

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Acta Neuropathologica Communications

ISSN: 2051-5960

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