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Fig. 10 | Acta Neuropathologica Communications

Fig. 10

From: Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse

Fig. 10

Using array tomography to assess the presence of synaptotoxic proteins. Representative images from a single region of interest (crop) captured within the LBC1936 EC (a + c) or the AD EC (b + d). Each image is a single plane from a 3D stack, which has been thresholded/binarised and single-slice objects removed to eliminate background. Sections were stained for synaptophysin, PSD95, and AW7 (a + b) or ApoE (c + d). Synaptically located staining is highlighted with white circles. c Scale bar = 2 μm

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