Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

Table 2 Statistically altered functional clusters of transcripts that are differentially expressed in SMAv vs. WTv

Down in SMAv		Up in SMAv
Cluster	Enrichment	Cluster	Enrichment
Ribsome	10.7	Metal Ion Binding	3.2
Mitochondrial Membrane	2.7	Nucleoplasm	3.2
Ubl Conjugation	2.3	RNA binding	2.6
Mitochondria	2.14	Transcriptional Regulation	2.5
Bone Development	1.6	Cytoskeleton	2.1
Mitochondrial Ribosome	1.55	mRNA processing	2.1
Focal Adhesion	1.52	Nuclear Speck	1.6
Mitochondrial Respiratory Chain	1.39	Chromatin Regulator	1.6
		Transcriptional Activator	1.6
		Cell death	1.3

Listed clusters are generated from functional annotations which were significantly enriched during functional annotation clustering. Significant enrichment was considered to be those clusters with an enrichment score of >1.3

ISSN: 2051-5960