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Table 1 Statistically altered functional clusters of transcripts that are differentially expressed in SMAv and SMAr compared to their respective WTs

From: Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

Down in SMA

Up in SMA

Cluster

Enrichment

Cluster

Enrichment

Ribosome/Translation

21.7

Repeat 2-2

2.4

Cytosolic Ribosome

4.7

RNA binding/Splicesosome

2.2

rRNA binding

4.4

Heat-shock

1.7

Ubiquitin

2.1

  

Oxidative Phosphorylation

1.6

  
  1. Listed clusters are generated from functional annotations which were significantly enriched during functional annotation clustering. Significant enrichment was considered to be those clusters with an enrichment score of >1.3
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Acta Neuropathologica Communications

ISSN: 2051-5960

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