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Fig. 8 | Acta Neuropathologica Communications

Fig. 8

From: Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

Fig. 8

Down-regulation of transcripts involved in oxidative phosphorylation. a Gene list show transcripts associated with oxidative phosphorylation which were statistically altered in SMAv and SMAr motor neurons compared to their respective wildtypes. Arrow indicates transcript that was investigated by qPCR. b, c Bar charts (Mean ± SEM) showing relative expression of haemoglobin beta chain (Hbb-b1) in WTv and SMAv motor neurons (b) and in WTv compared to WTr motor neurons. Note that qPCR results confirmed down-regulation of Hbb-b1 in SMAv motor neurons and also revealed an increase in Hbb-b1 levels in less vulnerable (WTr) motor neurons compared to vulnerable motor neuron (WTv). N = 4 biological replicates, each approximately 200 motor neurons from 2–3 mice. *P < 0.05 by Mann Whitney U test

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Acta Neuropathologica Communications

ISSN: 2051-5960

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