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Fig. 7 | Acta Neuropathologica Communications

Fig. 7

From: Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

Fig. 7

Down-regulation of transcripts involved in Ubiquitination. a Gene list show transcripts associated with ubiquitin which were statistically significantly altered in SMAv and SMAr motor neurons compared to their respective wildtypes. Arrow indicates transcript that was investigated by qPCR. b Bar chart (Mean ± SEM) showing relative expression of Ubiquitin (Ubb) in WTv and SMAv motor neurons. N = 4 biological replicates, each approximately 200 motor neurons from 2–3 mice. Note that qPCR results confirmed down-regulation of Ubb. ***P < 0.001 by Mann Whitney U test

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Acta Neuropathologica Communications

ISSN: 2051-5960

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