Fig. 6

Down-regulation of transcripts involved in the ribosome and rRNA binding. a Gene list show transcripts associated with the ribosome or rRNA binding which were statistically altered in SMAv and SMAr motor neurons compared to their respective wildtypes. No annotation implies just associated with the ribosome; *rRNA binding proteins and ribosome; ♯rRNA binding proteins not implicated in the ribosome. Arrow indicates transcripts that were investigated by qPCR. b Bar charts (Mean ± SEM) showing relative expression of RPL7, RPLP1, RPS27a, MRPL20 and LSM5 in WTv and SMAv motor neurons. N = 4 biological replicates, each approximately 200 motor neurons from 2–3 mice. Note that all qPCR results confirmed RNAseq results with the exception of LSM5 for which there was no change. ***P < 0.001, **P < 0.01 by Mann Whitney U test