Skip to main content
Fig. 4 | Acta Neuropathologica Communications

Fig. 4

From: Transcriptional profiling of differentially vulnerable motor neurons at pre-symptomatic stage in the Smn 2b/- mouse model of spinal muscular atrophy

Fig. 4

RNAseq results show large number of differentially regulated transcripts. a Schematic diagram shows number of statistically significant altered transcripts that were up or down regulated between the four experimental groups (WTr and SMAr, less vulnerable [cranial] motor neurons from wild-type and Smn 2B/- mice respectively; WTv and SMAv, vulnerable [abdominal/thoracic] motor neurons from wild-type and Smn 2B/- mice respectively). b-e Venn diagrams showing the number of common transcriptional changes between each of the primary comparisons which were made in panel a. Diagrams show number of changes which went down (b) or up (c) in both SMAv and SMAr motor neurons compared to their respective wild-types, and number of changes which went up (d) or down (e) in SMAv motor neurons compared to both SMAr and WTv motor neurons

Back to article page