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Table 1 Histological tumor classification

From: Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications

Tumour subtypes Study groups
TPAs APAs PCAs Total
Number % Number % Number % Number %
Densely granulated GH-cell adenomas 5 2.5 % 3 3.1 % 0 0.0 % 8 2.6 %
Sparsely granulated GH-cell adenomas 16 8.0 % 11 11.2 % 1 10.0 % 28 9.1 %
Mixed GH/PRL-cell adenomas 9 4.5 % 6 6.1 % 0 0.0 % 15 4.9 %
PRL-cell adenomas 64 32.0 % 32 32.7 % 2 20.0 % 98 31.8 %
Densely granulated ACTH-cell adenomas 19 9.5 % 8 8.2 % 0 0.0 % 27 8.8 %
Sparsely granulated ACTH-cell adenomas 49 24.5 % 20 20.4 % 0 0.0 % 69 22.4 %
ACTH-cell adenomas, NOS 0 0.0 % 0 0.0 % 7 70.0 % 7 2.3 %
TSH-cell adenomas 3 1.5 % 2 2.0 % 0 0.0 % 5 1.6 %
FSH/LH-cell adenomas 10 5.0 % 5 5.1 % 0 0.0 % 15 4.9 %
Null cell adenomas 25 12.5 % 11 11.2 % 0 0.0 % 36 11.7 %
Total 200 100 % 98 100 % 10 100 % 308 100 %
  1. The histological classification of each tumor analyzed in the groups of typical pituitary adenomas (TPA), atypical pituitary adenomas (APA) and pituitary carcinomas (PCA) is shown in detail. NOS not otherwise specified
  2. GH growth hormone, PRL prolactin, ACTH adrenocorticotrophic hormone, TSH thyroid-stimulating hormone, FSH follicle-stimulating hormone, LH luteinizing hormone
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