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Table 1 Histological tumor classification

From: Histological criteria for atypical pituitary adenomas – data from the German pituitary adenoma registry suggests modifications

Tumour subtypes

Study groups

TPAs

APAs

PCAs

Total

Number

%

Number

%

Number

%

Number

%

Densely granulated GH-cell adenomas

5

2.5 %

3

3.1 %

0

0.0 %

8

2.6 %

Sparsely granulated GH-cell adenomas

16

8.0 %

11

11.2 %

1

10.0 %

28

9.1 %

Mixed GH/PRL-cell adenomas

9

4.5 %

6

6.1 %

0

0.0 %

15

4.9 %

PRL-cell adenomas

64

32.0 %

32

32.7 %

2

20.0 %

98

31.8 %

Densely granulated ACTH-cell adenomas

19

9.5 %

8

8.2 %

0

0.0 %

27

8.8 %

Sparsely granulated ACTH-cell adenomas

49

24.5 %

20

20.4 %

0

0.0 %

69

22.4 %

ACTH-cell adenomas, NOS

0

0.0 %

0

0.0 %

7

70.0 %

7

2.3 %

TSH-cell adenomas

3

1.5 %

2

2.0 %

0

0.0 %

5

1.6 %

FSH/LH-cell adenomas

10

5.0 %

5

5.1 %

0

0.0 %

15

4.9 %

Null cell adenomas

25

12.5 %

11

11.2 %

0

0.0 %

36

11.7 %

Total

200

100 %

98

100 %

10

100 %

308

100 %

  1. The histological classification of each tumor analyzed in the groups of typical pituitary adenomas (TPA), atypical pituitary adenomas (APA) and pituitary carcinomas (PCA) is shown in detail. NOS not otherwise specified
  2. GH growth hormone, PRL prolactin, ACTH adrenocorticotrophic hormone, TSH thyroid-stimulating hormone, FSH follicle-stimulating hormone, LH luteinizing hormone