Fig. 1

Grading of the severity of amyloid angiopathy. Grade 1: scattered amyloid deposition presenting as a thin rim of Aβ positive fibers around the smooth muscle cell of the media (a and d); Grade 2: more extensive presence of amyloid in the vessel’s wall with focal replacement of the muscular layer (b and e); Grade 3: complete destruction of the wall by the severe amyloid deposition, present in most pial and superficial vessels (c and f). The absence of amyloid, grade 0 not shown in the figure. (4G8 anti amyloid antibody (a-f). Scale bars:a,b and c: 500 μm; d, e and f: 50 μm)