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Table 3 Relationship between pathological staging and clinical progression

From: Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways

  Stage 2 Stage 3 Stage 4 p-value
Gender (M:F) 5:3 10:6 6:3 0.628a
Mean age at onset (SD) 60 (9) 58 (6) 70 (8)* 0.007b
Mean age at death (SD) 61 (9) 61 (6) 71 (8)* 0.017b
Mean duration since diagnosis (SD) 1.5 (0.7) 3.5 (1.7)* 1.4 (0.6) 0.002b
Bulbar onset (N) 3 4 2 0.904a
Upper limb onset (N) 2 6 3
Lower limb onset (N) 3 6 4
  1. shading indicates p < 0.05
  2. aχ2 analysis
  3. bKruskall Wallis test
  4. *significantly different group using posthoc Mann–Whitney U test