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Table 3 Relationship between pathological staging and clinical progression

From: Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways

 

Stage 2

Stage 3

Stage 4

p-value

Gender (M:F)

5:3

10:6

6:3

0.628a

Mean age at onset (SD)

60 (9)

58 (6)

70 (8)*

0.007b

Mean age at death (SD)

61 (9)

61 (6)

71 (8)*

0.017b

Mean duration since diagnosis (SD)

1.5 (0.7)

3.5 (1.7)*

1.4 (0.6)

0.002b

Bulbar onset (N)

3

4

2

0.904a

Upper limb onset (N)

2

6

3

Lower limb onset (N)

3

6

4

  1. shading indicates p < 0.05
  2. aχ2 analysis
  3. bKruskall Wallis test
  4. *significantly different group using posthoc Mann–Whitney U test